The ISS will fly over the eastern United States during twilight tonight, crossing New Orleans, Washington (DC), New York and Boston. You’ll be able to see the ISS crossing directly overhead between 8:38pmCDT for New Orleans and other places in the Central Time Zone, 9:42pm EDT for the folks from Washington, DC and the Eastern Time Zone.
Map for the overflight, centered on Washington, DC, so you can see the path over the eastern United States.
For many locations, the track of the ISS through our skies will take it in front of the handle of the Big Dipper! The stars of the tail of the Great Bear may be hard to pick out of the bright twilight. I’ve found them easier to see after the ISS goes by, as the eye has something distant to focus on.
This fly-over is not a planned event specifically for the Eastern United States – it’s a consequence of orbital mechanics of the many loops the ISS takes around our planet.